The National Institutes of Health has funded a promising new study by scientists here at 23andMe that could help alleviate some of the existing disparities in genetics research between people of European and non-European ancestry.<img loading="lazy" decoding="async" class="alignright wp-image-21956 size-medium" src="http://35.88.189.111/wp-content/uploads/2014/11/Kasia1-197x300.jpg" alt="" width="197" height="300" srcset="https://blogcms.23andme.org/wp-content/uploads/2014/11/Kasia1-197x300.jpg 197w, https://blogcms.23andme.org/wp-content/uploads/2014/11/Kasia1.jpg 369w" sizes="auto, (max-width: 197px) 100vw, 197px" />
Some estimates show that <a href="https://www.nature.com/nature/journal/v475/n7355/full/475163a.html" target="_blank" rel="noopener noreferrer">more than 90 percent</a> of the research into the genetics underlying disease is on individuals of European descent alone. There are several reasons for this  – historical, cultural, economic, and social. The lack of diversity has meant that non-Europeans have not benefited from the huge advances in genetic research. Still, by leveraging 23andMe’s large and ethnically mixed customer base, researchers here think they can change that.
“This could help reduce the genetics research disparities among groups in the United States and elsewhere,” said Kasia Bryc, the senior scientist and population geneticist at 23andMe who will lead the research. “The scientific impact of findings from this research may be significant.”

Instead of using traditional genome-wide association studies to identify genetic variants associated with disease, this approach, called mapping by admixture linkage disequilibrium, or admixture mapping, takes advantage of the history of population mixing in the United States. Although admixture mapping was first suggested decades ago, leveraging 23andMe’s database would take it to a larger scale. 23andMe has more than 1.2 million customers, 80 percent of whom have consented to participate in research.
Although most of our customers are of European ancestry, our customer base includes large numbers of African Americans and Latinos. 23andMe has also gotten very good at estimating ancestry along the genome, which is crucial for detecting associations with disease via admixture mapping.
Mapping by admixture linkage disequilibrium works by tapping into variants or sets of variants found more frequently <img loading="lazy" decoding="async" class="alignright size-full wp-image-23763" src="https://www.23andme.org/blog/wp-content/uploads/2016/03/Pattern-of-Ancestry.jpg" alt="Pattern of Ancestry" width="188" height="449" srcset="https://blogcms.23andme.org/wp-content/uploads/2016/03/Pattern-of-Ancestry.jpg 188w, https://blogcms.23andme.org/wp-content/uploads/2016/03/Pattern-of-Ancestry-126x300.jpg 126w" sizes="auto, (max-width: 188px) 100vw, 188px" />within one ancestral group. In admixed populations – such as African Americans and Latinos who have mixed European, African, and Native American ancestry – using this method may be a way to more easily identify disease-causing variants.
Looking at individuals with specific diseases and where there is “enrichment” for one ancestry should highlight genetic regions associated with that disease, or so researchers hope. This is because the disease-causing variants occur more frequently in segments inherited from ancestral populations with a higher frequency of disease-associated variants.
23andMe’s research will determine whether admixture mapping could become a powerful tool complementary to large-scale genome-wide association studies.
Our researchers believe this work could help uncover genetic variants associated with disease in both people of European and non-European ancestry. However, because much of the genetic variation in Europeans has already been discovered, we expect this study to be most valuable in providing insights into biological variation for non-Europeans.
Beyond what the study could do to alleviate some of the huge disparities in health research among non-Europeans, the work could also help point the way in other areas, including guiding the development of drug targets.

23andMe Blog

23andMe Blog Team

23andMe Scientists Improving Diversity in Genetic Research

On Mother’s Day last year, Robin Butler’s children gave her 23andMe as a gift, not knowing it would change all their lives.
“I thought it would be fun to learn about my genome,” Robin said.<img loading="lazy" decoding="async" class="alignright size-full wp-image-23673" src="http://35.88.189.111/wp-content/uploads/2016/03/Robin-Quote.jpg" alt="" width="200" height="200" srcset="https://blogcms.23andme.org/wp-content/uploads/2016/03/Robin-Quote.jpg 200w, https://blogcms.23andme.org/wp-content/uploads/2016/03/Robin-Quote-150x150.jpg 150w" sizes="auto, (max-width: 200px) 100vw, 200px" />
But testing ultimately revealed something no one knew – the man she thought was her biological father wasn’t.
“I was in total shock for three days, and I am still dealing with the aftershocks,” Robin said. “My whole family was shocked. My mother was shocked, and so was the man we believed was my (biological) father for 49 years.”
23andMe allows people to explore what their genetics tell them about traits they might share with family, or about their health and ancestry. But doing the test can also reveal the unexpected. Sometimes those surprises can be fun, but, as in Robin’s case, they also have the potential to have profound implications.
For Robin, learning that her father wasn’t her biological father sent a shockwave through her family, but it didn’t tear them apart.
Robin had a unique relationship with the man she had known as her father. He and her mother had lived apart almost all of Robin’s life, and she had only lived with him briefly when she was 13. Although their relationship was distant, she embraced him as her father, just as any daughter would. Robin’s own children also knew him as their grandfather.
When her kids gave Robin 23andMe for Mother’s Day, she turned around and got a kit for her mother. When she got her results, she saw her connection to her mother in the DNA Relative feature and a third cousin she didn’t recognize. The two connected, trying to figure out how they were related. The cousin didn’t show up in her mother’s results, so Robin knew she had to be connected to the cousin on her father’s side, but she didn’t recognize any of the woman’s family names.
Robin had also gotten a kit for her dad for Father’s Day. When his results came back, they quickly realized he didn’t share any DNA with this third cousin or with Robin.
“I thought it was a mistake,” she said. “I even called 23andMe to confirm that the results were correct.”
But she also noticed that her father shared DNA with cousins who had names Robin knew.
“That’s when I knew that this was his DNA and he wasn’t my father,” she said. “That’s when I was thrown into shock.”
While the news was hard to accept, it didn’t devastate the family. Instead, it triggered many new questions for Robin about her family and herself.
It also propelled her on a new search.
“I knew I had to find my biological father,” Robin said.
Robin talked to her dad about it.
It wasn’t easy, but his response wasn’t anger or sadness but encouragement. He told her she needed answers that he didn’t have.
“I know you need to know,” he told her.
He understood how important it was to her.
“My dad helped in the search, too,” Robin said.
Looking at her 23andMe results, Robin returned to the third cousin with whom she first connected and noticed other second and third cousins. This prompted her to search for their surnames, which were unfamiliar to her. She got additional information from her mother, who had the first name of a man who was the only other likely person who could be Robin’s father. Pooling all this information together helped narrow her search. When she connected again with her third cousin and shared some of this information, they identified who they thought her father was. Her cousin even provided Robin with a picture, which Robin then showed to her parents. They recognized him immediately and said that was who they believed was her father.
“Remarkably, through my 23andme DNA relatives (and other information), I was able to find the man who I truly believe is my biological father, all within a matter of days,” Robin said.
But her cousin thought that Robin’s biological father had passed away. It wasn’t until Robin tracked down another cousin that she learned he was still alive. Using additional information, she was able to find an address. She took the next difficult step of sending him a carefully worded letter filled with details about her mother and her own connections through 23andMe with several of his relatives.
“I mailed the letter off on August 31, 2015, (and) I prayed to Jesus,” she said.
A few days later, Robin got an early morning phone call. It was him.
“Of course, this was a great shock to him and his family, but he called,” Robin said. “Thank God he called, and he remembered my mother. Like me, he just wanted to know the truth, and so did his wife of 47 years.”
He asked to do a DNA test, and Robin sent him a 23andMe kit. A few weeks later, the results confirmed what Robin thought – she’d found her biological father.
“His response was brief, and that&#8217;s the last I&#8217;ve heard from him,” Robin said. “I&#8217;m still waiting, but I have hope. I know I will have a relationship with my father.”
Robin is his only biological child. She doesn’t know how this news impacted him, but finding him was important in understanding herself.
It made her wonder what part of herself she inherited from her biological father and what was from her upbringing.
“I thought that knowing him would help me to better understand myself,” she said.
Making the connection gave her insight into where she came from.
“I not only found my biological father but I was introduced to extended family and ancestors that I hadn’t known of before,” said Robin. “Finding him and knowing about his family tree through our cousins made me feel complete and whole.”

A Need To Know

An accomplished scientist and businessman, Stephen Levine has spent his whole life <img loading="lazy" decoding="async" class="alignright size-thumbnail wp-image-23645" src="https://www.23andme.org/blog/wp-content/uploads/2016/03/Stephen-Levine-200x200.jpg" alt="Stephen Levine" width="200" height="200" />searching.


That restlessness is driven by a quest that is both emotional and intellectual, a desire to learn more about the world around him and himself. It was also driven by what he calls a deep emotional trauma. But that intense curiosity about who he was and where he came from was recently rewarded with a family connection he could have only made with the help of 23andMe.
“There is a lovely tender, tear rendering story here,” said Stephen, a Ph.D., who lives in Northern Washington and works in nutritional medicine.


He’d been adopted and grew up in Brooklyn in a family in which he felt alien and disconnected to his adoptive mother.
Using details from a story his adoptive mother told him about his birth, Stephen tracked down his biological mother when he was in his early 30s.
It wasn’t the kind of reunion he’d hoped for, however.
“She was a broken person, a street person,” he said.
His mother had agreed to meet him at a White Castle fast food restaurant in Brooklyn. It was a strange place for a mother and son reunion, and while he drove to the meeting, Stephen questioned whether he’d really found the right person at all.


“Intellectually I knew it was her, but emotionally I was so shaken up I just didn’t know,” he said.


But he thought to himself:
“If this is really my mom, then when I look at her face, I will know 100 percent,” he said. “And, she’ll have green eyes.”


Just after he parked his car at the restaurant a woman knocked on his window.
“I saw her face and I saw my face within it, with her green eyes,” he said.
Wanting to get to know her and learn more about his biological family, Stephen spent two days with her in a large hotel suite that he’d rented.
“She was obviously mentally imbalanced and depressed,” Stephen said. “I asked her many questions including the name of my biological father. She did give me his last name.”


After that initial meeting, he tried to develop a relationship with her, but it was too painful and difficult for her, he said. She eventually asked him to leave her alone.
His reunion with his mother stopped any additional searching for family for three decades until his own daughter, Ariel, reignited it when she tested with 23andMe.
Ariel’s 23andMe results showed a close connection with a woman she didn’t know. That woman, Marilyn, sent her a message. Marilyn wanted to figure out how they were so closely related. 23andMe showed that Marilyn was either Ariel’s aunt or a close cousin, and Marilyn’s father matched her as a grandfather.
Ariel told Marilyn, who was from Brooklyn, about her dad being adopted and originally being from Brooklyn. Marilyn and Stephen then connected and in an email exchange Marilyn asked Stephen if he knew his biological father’s last name. He told her he didn’t, only that it was a short name and started with “Z.”


“My maiden name is Zwick,” Marilyn emailed back.
“I knew in that instant, that this was the name that my mother had told me, over 30 years ago, and that this was my father’s family,” Stephen said. “I’ll never forget that moment.”
Stephen quickly booked a flight back to New York, renting an apartment where he met his sister Marilyn as well as his biological father and a collection of other relatives
At first his father, a retired sociology teacher, was standoffish, but as they talked it became obvious that Stephen was genuine. The two men looked a lot alike and even have similar mannerisms. At some point, it seemed to dawn on his biological father that Stephen was indeed his son.
He got up and walked over to Stephen, embracing him and saying:


“I have always wanted a son.”


It was more than Stephen could have hoped for, he said. They sat together and talked and Stephen learned that he and his father shared some of the same interests. They both liked doing yoga, meditation, and that they have some of the same sensibilities. For Stephen, who’d been searching for so long, meeting his biological family was a revelation.
“They accepted me,” Stephen said. “In my mind why should they love me, but they do. It’s very deep healing.”

Deep Healing

Listening to Wendy Spencer’s decades-long search for her biological father, the improbability of finding him, and then her shock after learning about the legacy of hatred he inherited from his own father, one would forgive Wendy if she decided to forget she ever found him.



<figure class="wp-block-image alignright wp-image-23624 size-medium"><img loading="lazy" decoding="async" width="300" height="225" src="http://35.88.189.111/wp-content/uploads/2016/02/wendy-spencer-a-1024-300x225.jpg" alt="" class="wp-image-23624" srcset="https://blogcms.23andme.org/wp-content/uploads/2016/02/wendy-spencer-a-1024-300x225.jpg 300w, https://blogcms.23andme.org/wp-content/uploads/2016/02/wendy-spencer-a-1024-768x576.jpg 768w, https://blogcms.23andme.org/wp-content/uploads/2016/02/wendy-spencer-a-1024-880x660.jpg 880w, https://blogcms.23andme.org/wp-content/uploads/2016/02/wendy-spencer-a-1024.jpg 1024w" sizes="auto, (max-width: 300px) 100vw, 300px" /><figcaption class="wp-element-caption">Wendy, right, her father, Bill, and her daughter Cosette.</figcaption></figure>



But Wendy thought perhaps her love and her family could change that legacy.



“I know people can change,&#8221; she said. &#8220;I have witnessed it before. I see it slowly happening.&#8221;



Wendy’s story of connecting with her biological father, Bill Miller, is a testament to using love to conquer hate, confronting the truth about her biological family’s history, and, even more broadly, coming to terms with America’s own history of racism. People magazine recently featured Wendy&#8217;s story and how she&#8217;s attempting to change that family legacy.



“With all the hate in the world and misunderstandings, I wish people could see each other as human beings with similar hopes and desires,” she said.







Wendy, a 50-year-old hair stylist in Sacramento, is Jewish. She married an African American man, and they have four children. One of their sons is married to a Latina, and the other is married to a Filipina. After learning from her mother more than two decades ago that she’d been conceived during an affair, she began searching for her biological father.



Last year, she tested with 23andMe. In October, when Wendy logged into her account right after her grandson’s brit milah, the Jewish circumcision ceremony, she had a notice that she had a new DNA relative. Thinking maybe she had found a new cousin, she clicked on the file.



“There was a picture of a man, it said ‘Father 50 percent match 24 segments,’” Wendy said. “Then his name, ‘William Miller.’ Needless to say, I was shocked my family heard me shout from the other room!”



She soon was able to connect with Bill. They exchanged email messages and then talked on the phone.



“We talked for an hour and a half,&#8221; Wendy said. &#8220;He cried off and on and seemed so happy.&#8221;



He’d told her that he had seen her twice after she was born but that when her parents moved and then later divorced, he’d lost track of her, although he never stopped looking. Wendy found out that he was in a cancer ward in San Antonio, recovering from surgery. She arranged to go and visit him and then flew to Texas.



He picked her up at the airport after being discharged from the hospital, and took her meet her great aunt, and a cousin.



“After a few family stories and my aunt pulling out pictures, the beginning of a nice connection was being made,” Wendy said.



The next day she went and stayed at her biological father’s house. He lived alone and had never married. The house was a wreck, but the visit allowed for Wendy to learn more about him and his family. It was almost too much for her to bear.



“He told me the reason he had the DNA test was because he was always concerned that he had a little African American in his DNA and he wanted to find out once and for all, (he does not),” she said. “It was very obvious that my dad is a racist!”



The more he talked, the more uncomfortable Wendy became as he put everyone in racial categories or sprinkled his conversation with racist terms.



“It was like a minor stab in the heart every time,” she said.



But she wanted to know “the good, the bad, and the ugly” about her biological family. Her father obliged, telling her about his father, Wendy&#8217;s grandfather, Emmett Elliot Miller.



“He told me his dad had done evil things,” she said.



Emmett Miller had been an organizer in the KKK.



He’d been involved in trying to bomb an all-black college and helped to organize the picket to stop the integration of schools in Little Rock, Arkansas.



“I felt sick to my stomach; the thought of getting up and leaving occurred to me,” she said. “At the same time, I felt God&#8217;s presence with me. It was a very gut-wrenching conversation.”



She told him how hurtful his racism was to her and asked that he stop using some of the racist words that were part of his vocabulary.



“I could tell his honesty was mixed with all the emotions he had been feeling,” she said. “This lonely older man was genuinely happy to have a daughter, grandchildren, and great-grandchildren, but his emotions were all mixed up, and he needed to share the conflict that was going on in his soul.”



His daughter is Jewish, married to a black man, and his grandchildren were all mixed, his great-grandchildren even more mixed.



Hearing her father&#8217;s stories about his family was almost too much for Wendy to process. She thought that even in her own lifetime as she was growing up in California surrounded by a family known for tolerance, her grandfather had been working so hard to prevent desegregation and the rights of black people to vote. When she eventually came home from Texas, Wendy said she was “an emotional wreck.”



She talked to her husband and her mother-in-law, who’d always had such sage advice about other matters. But on this, her mother-in-law had nothing to offer. Both of her mother-in-law&#8217;s parents had been murdered during the pre-civil rights era in Mississippi because of the color of their skin. Wendy&#8217;s mother in-law just didn&#8217;t have it in her to forgive.



“I’ve never seen my mother-in-law speechless, with no words of comfort or wisdom,” Wendy said. “She tried, but I could tell how shocking my news was to her.”



Still struggling with what she learned, Wendy continued to talk regularly with her biological father, and then he came to California to visit, arriving for Hanukkah. Wendy’s family welcomed him into their home. He stayed for five days, and became the center of attention. He connected particularly with Wendy’s son Michael and her youngest daughter Cosette. But on the fifth day of his visit, he stayed alone at home with Wendy’s husband. It did not go well.



But even after that, Wendy is trying to maintain the connection. Her father has sent Cosette gifts. He regularly emails, sends cards and calls.



From his point of view Bill said in a comment he made to People that although his language is sometime coarse he is not a racist or a bigot. At one point in the early 1960s, he and a friend were considering moving to Mississippi to help register voters, he has close friends who are Jewish and he regrets that there is tension between him and Wendy&#8217;s husband. <img decoding="async" class="ajT" src="https://ssl.gstatic.com/ui/v1/icons/mail/images/cleardot.gif" alt="">



“He says he loves me and does not deserve me,” Wendy said. “I am glad we have found each other.”



But she doesn&#8217;t know how it all will end up.



“I do not regret finding him and learning about the other half of me,” she said. “It has not been easy, but all of the story has been told.”

Ending a Legacy of Hate

<img loading="lazy" decoding="async" class="alignright size-full wp-image-23616" src="http://35.88.189.111/wp-content/uploads/2016/02/Screen-shot-2016-01-22-at-12.33.27-PM.jpg" alt="" width="232" height="288" />
The ability to extract and then sequence ancient DNA, not just from ancient human bones, but also from the bones of our ancient cousins the Neanderthals, is upending old notions of human migration and history.
<h2>Ancient DNA</h2>
The latest in a rapid succession of<a href="https://www.nature.com/news/evidence-mounts-for-interbreeding-bonanza-in-ancient-human-species-1.19394#Early"> new findings</a> suggests that intermixing between Neanderthals and early modern humans happened earlier than we once thought – about <a href="https://www.nature.com/articles/nature16544.epdf?referrer_access_token=CMEgDNGJuW7rNIX8-5DetdRgN0jAjWel9jnR3ZoTv0MInt_2jYvKBG--7sOqWdGTzUvToNHVvyhzE6mZLLgJJmR7yoinCDiE3vg9Q5AVA-nZquOQOOQnhcfdq9lCTp4TcwdkXstlNRZ7xfdZRcnYB6sIPffF_OSID_rECaKCbx-nDNFAoD9EQPv4N_1WWd-A8l0yEwuBeZ6eFt0-g5i0T9MPLVmGCIKRPC0jEsDeYZxD78jhZvPiTcPMjQJT5jr-&amp;tracking_referrer=www.nature.com">100,000 years ago</a> versus <a href="http://sriramsankararaman.com/publications/sankararaman.pgen.2012.pdf" target="_blank" rel="noopener noreferrer">50,000 years ago</a> – at a time that challenges long held theories about when humans migrated out of Africa and how far those migrations took them. And by looking at DNA sequences extracted from several different Neanderthal bones, researchers discovered that the gene flow didn’t just go from Neanderthals to humans.
This latest finding illustrates the impact DNA data, specifically data from ancient DNA, has had. <a href="https://www.theguardian.com/science/2014/feb/15/svante-paabo-dna-neanderthal-genetics">Svante Paabo</a> of the Max Planck Institute for Evolutionary Anthropology pioneered this innovation for extracting ancient DNA and accurately sequencing, and it radically transformed our understanding of human history.
<h2>New Information About the Past</h2>
Harvard population geneticist David Reich puts this new innovation into context in a long interview he did with<a href="http://edge.org/conversation/david_reich-the-genomic-ancient-dna-revolution"> The Edge</a>. Reich, who studies genetic variation among human populations, said that scientists have gained great new insights into history by comparing ancient DNA sequences to present-day humans’ genetic data.
“It’s a radically new type of information about the past; it’s a great gift to be able to have access to it,” Reich said in the interview. “It’s a great surprise. Who would have thought DNA survived that long?”
Probably the most profound insight from looking at ancient DNA and making comparisons with data from modern humans is that all human populations today are mixed.
<h2>Neanderthals and Modern Humans</h2>
This isn’t just about mixing between humans and Neanderthals, but mixing among early human populations and that data offers great insight into human history. He’s also looked at non-ancient human DNA to garner similar insights. So for example, Reich has looked at populations in India where they found that populations mixed there between 2000 to 4000 years ago. Before that there were unmixed populations.
“Amazingly, what you could see from the genetic data was an event in which you could see cultural change,” he said.
You can see something similar in more recent history by looking at the DNA of African Americans, which includes European ancestry, a clear mark of the slavery in the United States.
“What you’re seeing in the imprint of these populations genetically is the history of power inequality, which is usually males of power from one group having preferential access to local females, and that’s what you see in these groups,” Reich said.
Listen to Reich’s interview below.
The Edge Foundation, also has a video of his interview on its site<a href="http://edge.org/conversation/david_reich-the-genomic-ancient-dna-revolution"> here</a>.
<iframe loading="lazy" src="https://w.soundcloud.com/player/?url=https%3A//api.soundcloud.com/users/65424416&amp;auto_play=false&amp;hide_related=false&amp;show_comments=true&amp;show_user=true&amp;show_reposts=false&amp;visual=true" width="100%" height="450" frameborder="no" scrolling="no"></iframe>

Blast from the Past

Total strangers, John and Rhonda have one thing in common, the same father.<img loading="lazy" decoding="async" class="alignright wp-image-23484 size-medium" src="https://www.23andme.org/blog/wp-content/uploads/2016/01/JR-quote-300x169.jpg" alt="J$R quote" width="300" height="169" srcset="https://blogcms.23andme.org/wp-content/uploads/2016/01/JR-quote-300x169.jpg 300w, https://blogcms.23andme.org/wp-content/uploads/2016/01/JR-quote-768x432.jpg 768w, https://blogcms.23andme.org/wp-content/uploads/2016/01/JR-quote-880x495.jpg 880w, https://blogcms.23andme.org/wp-content/uploads/2016/01/JR-quote-980x553.jpg 980w, https://blogcms.23andme.org/wp-content/uploads/2016/01/JR-quote.jpg 984w" sizes="auto, (max-width: 300px) 100vw, 300px" />


The two made that discovery earlier this year after using 23andMe.


“Nobody knew about John,” said Rhonda, a 55 year-old marketer in Buffalo New York.


For John, recently retired and 67 who also lives in the Buffalo area, DNA testing was the only way he would have ever found Rhonda and information about his biological father. For both of them the test helped lead them to clues about their father and a tangled history of multiple families and an ongoing search for siblings spread out through generations and geography.
“I now have a printed family tree that  takes three trees to show and is  so long, it covers the top of two long tables,” said John. “(Testing has) been a positive experience for me and a healing experience for the family. I&#8217;ve been welcomed with open arms.”


Being orphaned, along with his half brother, from his single mom when he was just 10 had been so traumatic for John, that he blanked out all the memory of his childhood. He couldn’t even remember his mother’s face until a few years ago when he saw a photo of her for the first time. That had been out of sheer luck, after a mutual acquaintance connected him to his cousin and elderly aunt. John believes it may have been more than luck with a little help from his mother, watching from above.
It was his aunt and cousins who had the photo and tidbits about his mother. John and his family enjoyed a series of reunions in the US and in Italy over the past 5 years. His aunt also shared with John the one bit of information she had about his biological father, his father’s first name.
<div id="attachment_23482" style="width: 210px" class="wp-caption alignright"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-23482" class="size-thumbnail wp-image-23482" src="https://www.23andme.org/blog/wp-content/uploads/2016/01/John-Vitale-200x200.jpg" alt="John Vitale" width="200" height="200" />John Vitale</div>
“There is no way I could have identified the family on my father&#8217;s side,” he said. “All I had to go on was his name was Marvin, and I only learned that a couple of years ago.”


But for both John and Rhonda using 23andMe to explore their ancestry changed not just what they knew about their families and their background, but their understanding about themselves.
John had thought he was Italian, but was “shocked” to learn he was half Ashkenazi Jew on his father’s side.


“I knew nothing about my father, I assumed he was Italian,” said John. “My mother&#8217;s family is Italian with roots in Sicily and Milan.   I was raised Catholic.”
Learning about his Jewish ancestry, didn’t change his beliefs, but it did change his perceptions.


“It has made me more sensitive and curious of the Jewish faith,” he said.


For Rhonda, who was raised by a Jewish mother, learning about about her biological mother’s Catholic background put certain things about herself in context. It also raised a lot of “nature versus nurture issues” for her.


“I grew up as an only child, in a family that I was very different from,” she said. “I look nothing like, or act nothing like, my adopted mother or father.”


And then there was the connection she made using 23andMe to her biological family for the first time – not just to John, but also to a full sister named Trisha.
That connection with her sister was so strong that Rhonda wonders if there’s a chance that they might actually be twins separated and adopted out to different families.


“When I met Trisha, it felt like I was talking to myself,” Rhonda said. “The similarities were astounding.”


23andMe also helped Rhonda connect with her oldest living half-sibling, who is unrelated to John. She was one of the 2 children born to her mother when her mother was in an internment camp in Germany. It was that woman, Danuta, who gave Rhonda much of what she knows about her mother, including her mother’s history with Marvin and the other children she bore him.
<div id="attachment_23483" style="width: 210px" class="wp-caption alignright"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-23483" class="size-thumbnail wp-image-23483" src="https://www.23andme.org/blog/wp-content/uploads/2016/01/rhoried-pic-200x200.jpg" alt="Rhonda Ried" width="200" height="200" />Rhonda Ried</div>
All of Rhonda’s full siblings were adopted by other families, she said. At least two of whom she’s connected with through 23andMe. Rhonda discovered she has 5 full siblings and 6 half siblings, including John. And there could be more, she said.
Now both Rhonda and John are hoping that they will be able to connect with other siblings. They are aware of two sisters in Arizona.


“We are becoming acquainted with members of the family living around the country,” John said.


They have scheduled a virtual family reunion on Skype in a few weeks, but their search continues.


“I fully expect we’ll find others,” said John. “We’ll just keep looking.”

Nobody Knew

Abandoned as an infant in a Minneapolis laundry room almost 50 years ago, Liz Kellner used 23andMe to help <img loading="lazy" decoding="async" class="alignright size-thumbnail wp-image-21929" src="https://www.23andme.org/blog/wp-content/uploads/2014/11/Liz-Quote-200x200.jpg" alt="Liz Quote" width="200" height="200" />her piece together the story of her birth.
In the process, she was able to connect with a biological sister, Tammy, who like her had been abandoned as an infant; the sisters have pieced together their stories, connected with other siblings and even found their biological parents.


We first <a href="https://www.23andme.org/blog/ancestry/putting-it-together/">wrote about Liz</a> two years ago, and a few days ago, ABC News covered Liz and Tammy’s story.
Their story was also recently covered by the <a href="http://www.twincities.com/localnews/ci_29002587/woman-left-baby-at-st-paul-hospital-finds" target="_blank" rel="noopener noreferrer">Pioneer Press</a>. You can check out the ABC News piece below.
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<iframe loading="lazy" width="640" height="360" src="https://www.youtube.com/embed/thFNeUTh_iw" frameborder="0" allowfullscreen="allowfullscreen"></iframe>

Sisters Connecting After 50 Years

<div id="attachment_23295" style="width: 250px" class="wp-caption alignright"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-23295" class="wp-image-23295 size-full" src="https://www.23andme.org/blog/wp-content/uploads/2015/12/JohnBrian.jpg" alt="John&#038;Brian" width="240" height="294" />John, standing, with his sister Kathy and their half-brother Brian, who they found through 23andMe.</div>
Brothers from different mothers, John and Brian came together because of 23andMe.
For John, 68, finding a half-brother was the last thing he expected.
“I was shocked,” he said.
John used 23andMe because he’s interested in science. Since his days in high school biology class, John has always been curious about genetics. He wasn’t looking for family.
“Imagine my surprise when I found a half-brother,” he said.
Actually his results initially listed Brian as a predicted grandson – half siblings share about 20 percent of their DNA, the same percentage shared by a grandfather and grandson. There is also an 18-year difference in age between the two, so John had some tense moments trying to figure out his relationship with Brian.
But when Brian first contacted him by email, the message jarred loose a memory for John. He – and the rest of his immediate family – all knew that his Dad, who ran a photo studio in a coal-mining town in West Virginia, had had an affair with a woman who worked for him and that the woman got pregnant.
“We knew there was a child out there but that’s it,” said John, who eventually took over the family business.
<div id="attachment_23296" style="width: 235px" class="wp-caption alignright"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-23296" class="size-medium wp-image-23296" src="https://www.23andme.org/blog/wp-content/uploads/2015/12/Francis-John-Brians-Dad-225x300.jpg" alt="John and Brian's father." width="225" height="300" srcset="https://blogcms.23andme.org/wp-content/uploads/2015/12/Francis-John-Brians-Dad-225x300.jpg 225w, https://blogcms.23andme.org/wp-content/uploads/2015/12/Francis-John-Brians-Dad.jpg 240w" sizes="auto, (max-width: 225px) 100vw, 225px" />John and Brian&#8217;s father.</div>
Brian knew none of this.
He actually had no information at all about his biological family apart from some basic non-identifying facts about his mother – her religion and age for example.
Brian, a 49 year-old CPA living in Florida, often wondered about where he came from, but when he tested with 23andMe back in 2014 it was just to get some very basic information about his ancestry. He didn’t expect to find family.
When Brian first got his results he looked through his DNA Relative matches and among the long list of distant cousins, he saw one very close match, a relative with whom he shared 20 percent of his DNA.
“That’s close,” Brian said.
He just didn’t know how close. Looking at a 23andMe video Brian figured out that he and his close match were likely half siblings. For someone who’d never knew any biological relatives, this was a big deal. So Brian sent a message to his match and waited.
When John looked through the message from Brian and some of the facts he provided, he quickly figured out that Brian was his half brother. They began exchanging messages.
“I was a little leery about how he’d handle it,” said Brian. “It had to be shocking for him.”
Brian’s sister, who is also an adoptee, encouraged him to go forward with meeting John and his wife Jennie along with John’s sister Kathy and her husband Paul.
Brian didn’t just worry about how his existence would impact John and his family; he was also concerned about whether he’d be accepted. John and his family are religious and relatively conservative. His wife has a doctorate in theology and is a Christian counselor.
Brian was raised in a not very religious Jewish household, and he’s gay. He didn’t know what to expect.
“Over the years I imagined many different scenarios, so I went in with my eyes wide open,” Brian said.
John and his family welcomed him with open arms.
&#8220;I could not have asked for a nicer experience,” said Brian. “They were cordial, polite and respectful.&#8221;
John felt the same.
“It meant a lot to meet him,” said John. “I’m extremely impressed with Brian, his maturity and intelligence. He’s a good caring person.”
John also offered something to Brian that was invaluable, a vast collection of photos and even film of their biological father. Their father had run a photo studio business and was always taking pictures and filming.
Brian got to see his biological father at all these different stages of his life and even see how he moved, his mannerism and how he talked.
“It was more than I could have asked for,” Brian said.
Sharing that gave John his own sense of joy, he said.
Their father had a lot of flaws, John said, but everyone liked him. He had a big personality and John tried to share some of that with Brian.
“It meant a lot to me because it meant a lot to Brian,” John said.

Eyes Wide Open

Fast and sure on the ice, Olympic gold medalist <a href="http://apoloantonohno.com/">Apolo Anton Ohno</a> was less sure about his ancestral background.
<div id="attachment_23315" style="width: 295px" class="wp-caption alignright"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-23315" class="size-medium wp-image-23315" src="https://www.23andme.org/blog/wp-content/uploads/2015/12/Apolo-Ono-C-fixed-B-285x300-285x300.jpg" alt="Olympic gold medalist Apolo Ohno and Extreme Genes radio host Scott Fischer." width="285" height="300" />Olympic gold medalist Apolo Ohno and Extreme Genes radio host Scott Fischer.</div>
Raised by a single father, who’d immigrated to the United States from Japan, Apolo didn’t know much about his mother’s side of the family. On a recent episode of the syndicated family history radio show <a href="http://extremegenes.com/ep-115-olympic-gold-medalist-apolo-anton-ohno-dr-robin-smith-on-dna-week/">Extreme Genes</a>, Apolo said he turned to 23andMe to find out more about his ancestry. Along with the eight time Olympic medalist, the show featured 23andMe product scientist Robin Smith, PhD, who highlighted some of the company’s ancestry features and tools.
During his segment, Apolo explained that growing up outside of Seattle, he was sometimes asked about his nationality. “What are you?” is how the question was often asked.
“I’m half Japanese, but they’d ask what’s the other half,” Apolo told the show host Scott Fischer.
He didn’t know much about the other half of his ancestry.
His mother and father had divorced when he was very young and he stayed with his dad. He didn’t have much contact with his mother and because she’d been adopted she really didn’t know much about her family history.
But he was always curious about his ancestors, he said during the show.
On his Japanese side, he had a rich source of family lore not just from his grandmother, but because it is custom to carefully catalog the family going back generations. There are extensive household registries called koseki, as well as death records and records compiled by families themselves that helped Apolo trace back his Japanese family history. 
On his mother’s side, he had very little to go on. That’s why he turned to 23andMe. He learned the other half of his ancestry was rooted in England and Ireland, which might explain that even though his hair is black, his sideburns and goatee are red. He also learned that he has a little North African ancestry.
Apolo said his curiosity wasn’t just about learning about himself, but learning more generally about the human story. He mentioned reading about the discovery of 120,000 year old bones in China that change our understanding about the timing of human migration.
“It’s awesome,” he said of the science.
Before Apolo’s segment on the show, 23andMe scientist Robin Smith discussed some of 23andMe’s tools customers can use to explore not just their ancestry, but also their own connection to the human story.
Robin, who started his career as a geneticist focused on spinal cord regeneration, works on writing health and trait reports for 23andMe along with helping the company’s ancestry team develop features. One of the projects Robin worked on is 23andMe’s new Neanderthal report.
All humans outside of Africa carry DNA signatures of Neanderthals, a sister species to modern humans that went extinct about 35,000 years ago. Using new sequencing data, 23andMe can pinpoint where those Neanderthal variants show up in your genome, Robin said.
The report also looks at the different traits some of those variants are associated with – back hair and height, for instance.<img loading="lazy" decoding="async" class="alignnone size-large wp-image-23316" src="https://www.23andme.org/blog/wp-content/uploads/2015/12/Neanderthal-Report-640x397.jpg" alt="Neanderthal Report" width="640" height="397" />

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